What is the definition of pouch failure used in most clinical studies evaluating IPAA outcomes

What is known

- One study frames the outcome in terms of salvage: successful pouch salvage was defined as an intact, functioning pouch after resolution of the problem, with at least six months follow-up and good-to-excellent satisfaction and continence. ¹ - Reported pouch failure rates after IPAA are cited as ranging from about 5% to 18%. ²

What is unknown / caveats

- The retrieved excerpts do not give an explicit, standardized definition of pouch failure used across most IPAA outcome studies. - The excerpts note little consistency across studies regarding factors associated with failure.

## References

1. Shawki S, Belizon A, Person B, Weiss EG, Sands DR, Wexner SD. What are the outcomes of reoperative restorative proctocolectomy and ileal pouch-anal anastomosis surgery?. Dis Colon Rectum. 2009;52(5):884-90. PMID: 19502852.

2. Ricardo AP, Kayal M, Plietz MC, Khaitov S, Sylla P, Dubinsky MC, Greenstein A. Predictors of pouch failure: A tertiary care inflammatory bowel disease centre experience. Colorectal Dis. 2023;25(7):1469-1478. PMID: 37128185.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._