Top 100 Most-Cited Papers

The 100 most-cited papers across the IBD-unclassified literature, by citation count (NIH Open Citation Collection).

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

Silverberg MS · 2005 · Canadian journal of gastroenterology = Journal canadien de gastroenterologie · Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.2,695 cites
Levine A · 2014 · Journal of pediatric gastroenterology and nutrition · ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.1,097 cites
Fazio VW · 1995 · Annals of surgery · Ileal pouch-anal anastomoses complications and function in 1005 patients.958 cites
Beaugerie L · 2009 · Lancet (London, England) · Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.894 cites
Van Limbergen J · 2008 · Gastroenterology · Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease.743 cites
IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition · 2005 · Journal of pediatric gastroenterology and nutrition · Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria.536 cites
Fazio VW · 2013 · Annals of surgery · Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients.535 cites
Fraser AG · 2002 · Gut · The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review.507 cites
Uhlig HH · 2014 · Gastroenterology · The diagnostic approach to monogenic very early onset inflammatory bowel disease.502 cites
Strauss J · 2011 · Inflammatory bowel diseases · Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host.465 cites
Kuenzig ME · 2022 · Gastroenterology · Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review.462 cites
Solem CA · 2005 · Inflammatory bowel diseases · Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease.457 cites
MacDonald TT · 1990 · Clinical and experimental immunology · Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.441 cites
Vind I · 2006 · The American journal of gastroenterology · Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database.430 cites
Connell WR · 1993 · Gut · Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.425 cites
Heyman MB · 2005 · The Journal of pediatrics · Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.392 cites
Turner D · 2018 · Journal of pediatric gastroenterology and nutrition · Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.382 cites
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition · 2007 · Journal of pediatric gastroenterology and nutrition · Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America.351 cites
Colman RJ · 2014 · Journal of Crohn's & colitis · Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis.344 cites
Burisch J · 2014 · Gut · East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort.311 cites
Hahnloser D · 2007 · The British journal of surgery · Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis.297 cites
Sýkora J · 2018 · World journal of gastroenterology · Current global trends in the incidence of pediatric-onset inflammatory bowel disease.290 cites
Conte MP · 2006 · Gut · Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.286 cites
Peeters M · 2001 · The American journal of gastroenterology · Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease.272 cites
Yu YR · 2017 · Seminars in pediatric surgery · Clinical presentation of Crohn's, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes.265 cites
Bassi A · 2004 · Gut · Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study.253 cites
Romberg-Camps MJ · 2009 · The American journal of gastroenterology · Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease.246 cites
Ljung T · 2004 · Gut · Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County.242 cites
Aadland E · 1987 · Scandinavian journal of gastroenterology · Primary sclerosing cholangitis: a long-term follow-up study.241 cites
Bourreille A · 2009 · Endoscopy · Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus.240 cites
Papadakis KA · 2001 · The American journal of gastroenterology · Outcome of cytomegalovirus infections in patients with inflammatory bowel disease.228 cites
Robles AI · 2016 · Gastroenterology · Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.222 cites
Joossens S · 2002 · Gastroenterology · The value of serologic markers in indeterminate colitis: a prospective follow-up study.222 cites
Ye Y · 2020 · Inflammatory bowel diseases · Prevalence of Inflammatory Bowel Disease in Pediatric and Adult Populations: Recent Estimates From Large National Databases in the United States, 2007-2016.210 cites
Silvennoinen JA · 1995 · Gut · A controlled study of bone mineral density in patients with inflammatory bowel disease.205 cites
Vavricka SR · 2012 · Inflammatory bowel diseases · Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease.204 cites
Ng SC · 2019 · The American journal of gastroenterology · Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific.201 cites
Romberg-Camps MJ · 2010 · Inflammatory bowel diseases · Fatigue and health-related quality of life in inflammatory bowel disease: results from a population-based study in the Netherlands: the IBD-South Limburg cohort.194 cites
Maurer M · 2006 · Water research · Treatment processes for source-separated urine.194 cites
Vavricka SR · 2015 · Inflammatory bowel diseases · Chronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort.191 cites
Bunn SK · 2001 · Journal of pediatric gastroenterology and nutrition · Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease.191 cites
Mountifield R · 2009 · Inflammatory bowel diseases · Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions.189 cites
Molinié F · 2004 · Gut · Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988-1999).187 cites
Everhov ÅH · 2018 · Gastroenterology · Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden.184 cites
Kunitake H · 2008 · Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · Perioperative treatment with infliximab in patients with Crohn's disease and ulcerative colitis is not associated with an increased rate of postoperative complications.184 cites
Castaño-Rodríguez N · 2017 · Gut · Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis.181 cites
Hyams JS · 2017 · Gastroenterology · Infliximab Is Not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease.178 cites
Boonstra K · 2012 · Inflammatory bowel diseases · Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease.175 cites
Long MD · 2011 · Inflammatory bowel diseases · Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease.173 cites
Lutgens MW · 2008 · Gut · High frequency of early colorectal cancer in inflammatory bowel disease.169 cites
Jose FA · 2009 · Inflammatory bowel diseases · Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease.167 cites
Pera A · 1987 · Gastroenterology · Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score.166 cites
Jones GR · 2019 · Gut · IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology.165 cites
Malaty HM · 2010 · Journal of pediatric gastroenterology and nutrition · Rising incidence of inflammatory bowel disease among children: a 12-year study.164 cites
Henderson P · 2012 · Inflammatory bowel diseases · Rising incidence of pediatric inflammatory bowel disease in Scotland.162 cites
Kappelman MD · 2014 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Evaluation of the patient-reported outcomes measurement information system in a large cohort of patients with inflammatory bowel diseases.161 cites
Jakobsson GL · 2017 · Scandinavian journal of gastroenterology · Validating inflammatory bowel disease (IBD) in the Swedish National Patient Register and the Swedish Quality Register for IBD (SWIBREG).161 cites
Tomasello G · 2016 · Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases.158 cites
Parente F · 2003 · Alimentary pharmacology & therapeutics · Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel.157 cites
Billioud V · 2013 · Journal of Crohn's & colitis · Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis.156 cites
Hildebrand H · 2003 · Gut · Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.156 cites
Ouahed J · 2020 · Inflammatory bowel diseases · Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.155 cites
Gower-Rousseau C · 2013 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · Epidemiology of inflammatory bowel diseases: new insights from a French population-based registry (EPIMAD).155 cites
Moum B · 1996 · Scandinavian journal of gastroenterology · Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists.155 cites
Bossuyt X · 2006 · Clinical chemistry · Serologic markers in inflammatory bowel disease.154 cites
DeRoche TC · 2014 · Gastroenterology report · Histological evaluation in ulcerative colitis.153 cites
Auvin S · 2005 · Journal of pediatric gastroenterology and nutrition · Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999).153 cites
Prideaux L · 2012 · Inflammatory bowel diseases · Serological antibodies in inflammatory bowel disease: a systematic review.152 cites
Sagar PM · 1996 · Diseases of the colon and rectum · Long-term results of ileal pouch-anal anastomosis in patients with Crohn's disease.151 cites
Tontini GE · 2015 · World journal of gastroenterology · Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives.149 cites
Yu H · 2018 · Alimentary pharmacology & therapeutics · Market share and costs of biologic therapies for inflammatory bowel disease in the USA.148 cites
Schreiber S · 2019 · Annals of the rheumatic diseases · Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials.148 cites
Shelton E · 2015 · Inflammatory bowel diseases · Efficacy of Vedolizumab as Induction Therapy in Refractory IBD Patients: A Multicenter Cohort.148 cites
Abraham BP · 2012 · Journal of clinical gastroenterology · Natural history of pediatric-onset inflammatory bowel disease: a systematic review.147 cites
Wilson J · 2010 · Inflammatory bowel diseases · High incidence of inflammatory bowel disease in Australia: a prospective population-based Australian incidence study.146 cites
Ferrante M · 2008 · Inflammatory bowel diseases · Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.146 cites
Fellermann K · 1998 · The American journal of gastroenterology · Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506).145 cites
Lakatos L · 2011 · Inflammatory bowel diseases · Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002-2006.145 cites
Lightner AL · 2017 · Inflammatory bowel diseases · Results at Up to 30 Years After Ileal Pouch-Anal Anastomosis for Chronic Ulcerative Colitis.145 cites
Feakins RM · 2013 · Journal of clinical pathology · Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines.144 cites
Yu CS · 2000 · Diseases of the colon and rectum · Ileal pouch-anal anastomosis in patients with indeterminate colitis: long-term results.143 cites
Mow WS · 2004 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy.140 cites
Moskovitz DN · 2004 · The American journal of gastroenterology · The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients.140 cites
Brant SR · 2017 · Gastroenterology · Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.138 cites
Vester-Andersen MK · 2014 · The American journal of gastroenterology · Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy.138 cites
Fischer M · 2016 · Inflammatory bowel diseases · Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease.138 cites
Ghione S · 2018 · The American journal of gastroenterology · Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.138 cites
Lindberg E · 2000 · Journal of pediatric gastroenterology and nutrition · Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995.136 cites
Rahier JF · 2010 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.135 cites
Weimers P · 2019 · Inflammatory bowel diseases · Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study.134 cites
Turunen P · 2006 · Inflammatory bowel diseases · Incidence of inflammatory bowel disease in Finnish children, 1987-2003.134 cites
Pinsk V · 2007 · The American journal of gastroenterology · Inflammatory bowel disease in the South Asian pediatric population of British Columbia.131 cites
Reddy D · 2008 · The American journal of gastroenterology · Relapses of inflammatory bowel disease during pregnancy: in-hospital management and birth outcomes.131 cites
Lu Y · 2009 · The American journal of gastroenterology · Immune response to influenza vaccine in children with inflammatory bowel disease.130 cites
Dotson JL · 2010 · Journal of pediatric gastroenterology and nutrition · Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity.130 cites
Burisch J · 2020 · The lancet. Gastroenterology & hepatology · Health-care costs of inflammatory bowel disease in a pan-European, community-based, inception cohort during 5 years of follow-up: a population-based study.129 cites
Razanskaite V · 2017 · Journal of Crohn's & colitis · Biosimilar Infliximab in Inflammatory Bowel Disease: Outcomes of a Managed Switching Programme.128 cites
Smits LJ · 2016 · Journal of Crohn's & colitis · Clinical Outcomes Following a Switch from Remicade® to the Biosimilar CT-P13 in Inflammatory Bowel Disease Patients: A Prospective Observational Cohort Study.126 cites
Brotherton CS · 2016 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · Avoidance of Fiber Is Associated With Greater Risk of Crohn's Disease Flare in a 6-Month Period.124 cites
Seyrig JA · 1985 · Digestive diseases and sciences · Idiopathic pancreatitis associated with inflammatory bowel disease.123 cites