Top Cited

The 100 most-cited studies across the IBD-unclassified literature, by citation count (NIH Open Citation Collection).

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the IBD-unclassified literature.

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

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1Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
Silverberg MS · 2005 · Can J Gastroenterol
2,706
2ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.
Levine A · 2014 · J Pediatr Gastroenterol Nutr
1,109
3Ileal pouch-anal anastomoses complications and function in 1005 patients
Fazio · 1995 · Ann Surg
959
4Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.
Beaugerie L · 2009 · Lancet
895
5Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease.
Van Limbergen J · 2008 · Gastroenterology
744
6Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
2015 · Endoscopy
582
7Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria.
IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition · 2005 · J Pediatr Gastroenterol Nutr
536
8Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients
Fazio · 2013 · Ann Surg
536
9The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH · 2014 · Gastroenterology
508
10The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review.
Fraser AG · 2002 · Gut
507
11Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review.
Kuenzig ME · 2022 · Gastroenterology
474
12Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host.
Strauss J · 2011 · Inflamm Bowel Dis
468
13Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease.
Solem CA · 2005 · Inflamm Bowel Dis
458
14Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.
MacDonald TT · 1990 · Clin Exp Immunol
441
15Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database.
Vind · 2006 · Am J Gastroenterol
430
16Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.
Connell WR · 1993 · Gut
425
17Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.
Heyman MB · 2005 · J Pediatr
394
18Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Turner · 2018 · J Pediatr Gastroenterol Nutr
387
19Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America.
Bousvaros · 2007 · J Pediatr Gastroenterol Nutr
351
20Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis.
Colman RJ · 2014 · J Crohns Colitis
345
21East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort.
Burisch J · 2014 · Gut
312
22The risk of retention of the capsule endoscope in patients with known or suspected Crohn's disease.
2006 · Am J Gastroenterol
298
23Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis
Hahnloser · 2007 · Br J Surg
297
24Current global trends in the incidence of pediatric-onset inflammatory bowel disease.
Sýkora J · 2018 · World J Gastroenterol
291
25Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease.
Conte MP · 2006 · Gut
287
26Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease.
Peeters M · 2001 · Am J Gastroenterol
272
27Clinical presentation of Crohn's, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes.
Yu YR · 2017 · Semin Pediatr Surg
267
28Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study.
Bassi A · 2004 · Gut
253
29Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease.
Romberg-Camps · 2009 · Am J Gastroenterol
246
30Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County.
Ljung · 2004 · Gut
242
31Primary sclerosing cholangitis: a long-term follow-up study.
Aadland E · 1987 · Scand J Gastroenterol
242
32Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus
Bourreille · 2009 · Endoscopy
240
33Outcome of cytomegalovirus infections in patients with inflammatory bowel disease.
Papadakis · 2001 · Am J Gastroenterol
228
34The value of serologic markers in indeterminate colitis: a prospective follow-up study.
Joossens S · 2002 · Gastroenterology
222
35Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.
Robles AI · 2016 · Gastroenterology
221
36Prevalence of Inflammatory Bowel Disease in Pediatric and Adult Populations: Recent Estimates From Large National Databases in the United States, 2007-2016.
Ye Y · 2020 · Inflamm Bowel Dis
213
37Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease.
Vavricka SR · 2012 · Inflamm Bowel Dis
207
38A controlled study of bone mineral density in patients with inflammatory bowel disease.
Silvennoinen · 1995 · Gut
205
39Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific.
Ng SC · 2019 · Am J Gastroenterol
204
40Fatigue and health-related quality of life in inflammatory bowel disease: results from a population-based study in the Netherlands: the IBD-South Limburg cohort.
Romberg-Camps MJ · 2010 · Inflamm Bowel Dis
196
41Chronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort.
Vavricka SR · 2015 · Inflamm Bowel Dis
194
42Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease.
Bunn SK · 2001 · J Pediatr Gastroenterol Nutr
191
43Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions.
Mountifield R · 2009 · Inflamm Bowel Dis
190
44Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988-1999).
Molinié F · 2004 · Gut
187
45Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden.
Everhov ÅH · 2018 · Gastroenterology
185
46Perioperative treatment with infliximab in patients with Crohn's disease and ulcerative colitis is not associated with an increased rate of postoperative complications.
Kunitake H · 2008 · J Gastrointest Surg
184
47Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis.
Castaño-Rodríguez N · 2017 · Gut
181
48Infliximab Is Not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease.
Hyams JS · 2017 · Gastroenterology
179
49Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease.
Boonstra · 2012 · Inflamm Bowel Dis
175
50Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease.
Long MD · 2011 · Inflamm Bowel Dis
173
51High frequency of early colorectal cancer in inflammatory bowel disease.
Lutgens MW · 2008 · Gut
170
52Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease.
Jose FA · 2009 · Inflamm Bowel Dis
167
53IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology.
Jones GR · 2019 · Gut
167
54Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score.
Pera A · 1987 · Gastroenterology
166
55Rising incidence of inflammatory bowel disease among children: a 12-year study.
Malaty HM · 2010 · J Pediatr Gastroenterol Nutr
164
56Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases.
Tomasello G · 2016 · Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
162
57Evaluation of the patient-reported outcomes measurement information system in a large cohort of patients with inflammatory bowel diseases.
Kappelman MD · 2014 · Clin Gastroenterol Hepatol
162
58Rising incidence of pediatric inflammatory bowel disease in Scotland.
Henderson P · 2012 · Inflamm Bowel Dis
162
59Validating inflammatory bowel disease (IBD) in the Swedish National Patient Register and the Swedish Quality Register for IBD (SWIBREG).
Jakobsson GL · 2017 · Scand J Gastroenterol
161
60Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.
Ouahed J · 2020 · Inflamm Bowel Dis
158
61Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel.
Parente F · 2003 · Aliment Pharmacol Ther
158
62Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis.
Billioud · 2013 · J Crohns Colitis
157
63Epidemiology of inflammatory bowel diseases: new insights from a French population-based registry (EPIMAD).
Gower-Rousseau C · 2013 · Dig Liver Dis
156
64Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.
Hildebrand H · 2003 · Gut
156
65Histological evaluation in ulcerative colitis
DeRoche · 2014 · Gastroenterol Rep (Oxf)
155
66Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists.
Moum B · 1996 · Scand J Gastroenterol
155
67Serologic markers in inflammatory bowel disease.
Bossuyt X · 2006 · Clin Chem
154
68Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999).
Auvin S · 2005 · J Pediatr Gastroenterol Nutr
153
69Serological antibodies in inflammatory bowel disease: a systematic review.
Prideaux · 2012 · Inflamm Bowel Dis
152
70Long-term results of ileal pouch-anal anastomosis in patients with Crohn's disease
Sagar · 1996 · Dis Colon Rectum
151
71Market share and costs of biologic therapies for inflammatory bowel disease in the USA.
Yu H · 2018 · Aliment Pharmacol Ther
149
72Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives.
Tontini GE · 2015 · World J Gastroenterol
149
73Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials.
Schreiber S · 2019 · Ann Rheum Dis
149
74Efficacy of Vedolizumab as Induction Therapy in Refractory IBD Patients: A Multicenter Cohort
Shelton · 2015 · Inflamm Bowel Dis
148
75Natural history of pediatric-onset inflammatory bowel disease: a systematic review.
Abraham · 2012 · J Clin Gastroenterol
147
76High incidence of inflammatory bowel disease in Australia: a prospective population-based Australian incidence study.
Wilson J · 2010 · Inflamm Bowel Dis
146
77Results at Up to 30 Years After Ileal Pouch-Anal Anastomosis for Chronic Ulcerative Colitis
Lightner · 2017 · Inflamm Bowel Dis
146
78Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis
Ferrante · 2008 · Inflamm Bowel Dis
146
79Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines.
Feakins RM · 2013 · J Clin Pathol
145
80Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506)
Fellermann · 1998 · Am J Gastroenterol
145
81Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002-2006.
Lakatos · 2011 · Inflamm Bowel Dis
145
82Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.
Brant SR · 2017 · Gastroenterology
143
83Ileal pouch-anal anastomosis in patients with indeterminate colitis: long-term results
Yu · 2000 · Dis Colon Rectum
143
84High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy.
Mow WS · 2004 · Clin Gastroenterol Hepatol
140
85Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.
Ghione S · 2018 · Am J Gastroenterol
140
86The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients.
Moskovitz DN · 2004 · Am J Gastroenterol
140
87Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease.
Fischer · 2016 · Inflamm Bowel Dis
139
88Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy.
Vester-Andersen · 2014 · Am J Gastroenterol
138
89Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995.
Lindberg E · 2000 · J Pediatr Gastroenterol Nutr
136
90Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study.
Weimers P · 2019 · Inflamm Bowel Dis
135
91Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.
Rahier JF · 2010 · Clin Gastroenterol Hepatol
135
92Incidence of inflammatory bowel disease in Finnish children, 1987-2003.
Turunen · 2006 · Inflamm Bowel Dis
134
93Inflammatory bowel disease in the South Asian pediatric population of British Columbia.
Pinsk V · 2007 · Am J Gastroenterol
132
94Relapses of inflammatory bowel disease during pregnancy: in-hospital management and birth outcomes.
Reddy · 2008 · Am J Gastroenterol
132
95Immune response to influenza vaccine in children with inflammatory bowel disease.
Lu Y · 2009 · Am J Gastroenterol
131
96The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence.
Ferrante · 2006 · Gastroenterology
131
97Health-care costs of inflammatory bowel disease in a pan-European, community-based, inception cohort during 5 years of follow-up: a population-based study.
Burisch J · 2020 · Lancet Gastroenterol Hepatol
130
98Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity.
Dotson JL · 2010 · J Pediatr Gastroenterol Nutr
130
99Biosimilar Infliximab in Inflammatory Bowel Disease: Outcomes of a Managed Switching Programme.
Razanskaite V · 2017 · J Crohns Colitis
128
100Clinical Outcomes Following a Switch from Remicade® to the Biosimilar CT-P13 in Inflammatory Bowel Disease Patients: A Prospective Observational Cohort Study.
Smits LJ · 2016 · J Crohns Colitis
126