Does stapled ileoanal anastomosis increase the risk of de novo CD compared with hand-sewn anastomosis after IPAA for UC

What is known

- The studies that report de novo Crohn's disease rates after IPAA compare underlying diagnosis (ulcerative colitis vs IBD-unclassified/indeterminate colitis), not anastomotic technique. ^1,2

What is unknown / caveats

- The retrieved excerpts do not report a direct comparison of stapled versus hand-sewn ileoanal anastomosis with respect to the risk of de novo Crohn's disease after IPAA.

## References

1. Zaghiyan K, Kamiński JP, Barmparas G, Fleshner P. De novo Crohn's Disease after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis and Inflammatory Bowel Disease Unclassified: Long-Term Follow-Up of a Prospective Inflammatory Bowel Disease Registry. Am Surg. 2016;82(10):977-981. PMID: 27779987.

2. Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Dis Colon Rectum. 2009;52(5):872-8. PMID: 19502850.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._